Stem Cell and Developmental Biology

Prof. Dr. Ulrike Nuber

The goal of our research is to contribute to a better understanding and the development of improved therapies for two brain diseases that affect children: pediatric brain tumors and Rett syndrome.

Translational neuroscience research is particularly challenging for two major reasons: The complexity of the nervous system and the inaccessibility of human diseased cell and tissue material. To overcome the latter problem, we generate and apply stem cell-based disease models for pediatric brain tumors and Rett syndrome.

In our brain tumor projects, we study how neural stem and progenitor cells turn into tumorigenic cells and apply this knowledge to identify and test novel therapeutic agents that inhibit brain tumor growth. In our projects on Rett syndrome, we investigate the cellular effects of mutations in the disease gene MECP2. We aim to translate insight gained by this research into improved therapeutic approaches utilizing human induced pluripotent stem cells as a Rett syndrome disease model.