Large Molecules Transported into Living Cells

Scientists at TU Darmstadt and the Leibniz Research Institute for Molecular Pharmacology (FMP) in Berlin have investigated how large functional biomolecules like proteins or antibodies can be brought into a living cell. Linking antibodies or proteins with cell-penetrating peptides is a promising approach—but it has not yet fully led to the anticipated results. If these peptides are also attached to the cell surface, then proteins or antibodies are transported much better into the cell interior. The groundbreaking results have just been published in the journal Nature Chemistry.

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