Methyl Magic - Magicians of life

24.07.2017

Methyl Magic – Magicians of life

Photo courtesy of Katrin Lindner (www.foreverdesigns.de)
Photo courtesy of Katrin Lindner (www.foreverdesigns.de)

„Methyl Magic: a small chemical modification on the DNA with a big impact on how our genetic information is read and translated into normal physiology and disease.“

In a series of recent publications, the Cardoso laboratory, in collaboration with groups from the USA (Zhao laboratory), Munich (Leonhardt laboratory) and the Nuber laboratory have found that a series of methyl readers can guard this small group against its further chemical modification and eventual loss. The misregulation of this process in neurological disorders (Rett syndrome) is accompanied by transcriptional noise and genome instability.

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